01
History
Prenatal/birth course; maternal blood type, HBsAg, HIV, STI and GBS results; medications/exposures; family history; feeding, elimination, sleep, safety and support.
Academy · Prevention · Pediatrics
A high-yield reference for birth hospitalization and the first check.
Verify newborn history, examination, universal screening, prophylaxis, feeding, discharge counseling, and individualized pathways without opening a full guideline document.
Clinician quick view
Birth hospitalization plus first-week follow-up at 3–5 days. Routine and individualized care are separated deliberately.
01
Prenatal/birth course; maternal blood type, HBsAg, HIV, STI and GBS results; medications/exposures; family history; feeding, elimination, sleep, safety and support.
02
Weight, length, head circumference and WHO trajectory; vitals; complete newborn examination including red reflex, pulses, hips, cord, jaundice, tone and reflex symmetry.
03
Surveil symmetric movement, primitive reflexes, sound response, brief fixation, state regulation, feeding cues and consolability. No routine formal developmental screen.
04
Bloodspot 24–48 h; hearing before discharge/by 1 mo; CCHD ≥24 h or before early discharge; TcB/TSB 24–48 h or before early discharge.
05
HepB by weight and maternal HBsAg pathway; RSV by season and maternal vaccination; IM vitamin K; erythromycin eye ointment.
06
Observed feeding before discharge and at 3–5 d; 8–12 feeds/24 h; assess output. Evaluate >7% loss by day 3–5 or >10% at any time.
07
Jaundice, fever/illness, ABC safe sleep, rear-facing car seat, cord care, hand hygiene, sick contacts and result follow-up.
08
Breast milk or iron-fortified formula, supervised awake tummy time, bonding/support, smoke-free care and avoidance of impaired caregiving.
09
Prematurity/<2,000 g, HBsAg positive/unknown, Rh-/type O, G6PD risk, substance exposure, home birth, abnormal screen, congenital anomaly, RSV history/season, vitamin K refusal and elective circumcision.
10
Confirm 3–5-day visit for weight, bilirubin and feeding reassessment; establish medical home and closed-loop screening-result follow-up.
Medical prevention
Examine, screen, immunize, provide prophylaxis, and identify illness early.
Lifestyle prevention
Support feeding, safe sleep, awake play, relationships, and exposure avoidance.
Detailed reference · History
Detailed reference · Growth, examination & development
Color, tone, activity, cry, gestational-age assessment; Moro, suck, grasp, rooting and movement symmetry.
Fontanelles, sutures, molding, cephalohematoma/caput; red reflex and pupils; ear position, pits and tags.
Murmur, femoral pulses, respiratory effort/rate, retractions and grunting; pulse oximetry under CCHD screening.
Cord vessels, organomegaly, hernia; testes, hypospadias or ambiguity; Ortolani and Barlow maneuvers.
Sacral dimples, tufts or masses; jaundice, birthmarks, rashes and skin integrity. Visual inspection alone is insufficient for bilirubin risk.
Symmetric movement, flexion, head turn, reflexes, sound response, brief fixation, state changes, consolability and feeding cues.
Persistent hypotonia or hypertonia, absent or asymmetric primitive reflexes, seizure-like activity, poor feeding or suck, lack of response to auditory stimuli, or dysmorphic features warrant evaluation. Formal developmental screening is not routine at the newborn visit.
Detailed reference · Recommended screening
Universal at 24–48 hours; exact disorders vary by state.
Follow the state program. Abnormal results require immediate state-protocol follow-up and confirmatory testing. Verify the current RUSP and state-specific panel rather than relying on a fixed condition count.
HHS/ACHDNC, state programs, ACOG 2019
Before discharge; no later than 1 month. OAE or automated ABR.
USPSTF Grade B. The supplied EHDI goal is diagnosis by 3 months and intervention by 6 months. Family history may warrant heightened follow-up.
JCIH, AAP, USPSTF Grade B
Pre- and post-ductal pulse oximetry at ≥24 hours, or before an earlier discharge.
AAP 2025 algorithm: ≥95% at both sites to pass, with one retest after an initial failed screen.
AAP 2025 CCHD clinical report; RUSP
TcB or TSB at 24–48 hours, or before an earlier discharge.
AAP 2022 KAS 5. Confirm TcB with TSB when within 3 mg/dL of the phototherapy threshold or TcB ≥15 mg/dL. Determine follow-up from the difference between the measured value and phototherapy threshold, not the prior risk-zone nomogram alone.
AAP 2022 hyperbilirubinemia guideline; KAS 5 recommendation
For maternal type O, Rh-negative, or unknown blood type.
Cord-blood DAT is specified when maternal blood is Rh-negative or type O; heighten jaundice surveillance. Exact primary guideline details were not supplied.
Primary guideline details unavailable in the reviewed evidence
Consider for specified ancestry, particularly with severe or unexplained jaundice.
The reviewed guidance identifies males of African, Mediterranean, Middle Eastern, or Southeast Asian descent. Exact timing and primary recommendation details were unavailable.
Primary guideline details unavailable in the reviewed evidence
For suspected prenatal exposure based on history or clinical signs.
Urine or meconium methods are described. Maternal substance use also triggers NAS surveillance and may alter hospitalization and social-work involvement.
Primary guideline details unavailable in the reviewed evidence
Surveil now; institutional birth-hospital screening varies. Formal AAP screening starts at 1 month.
AAP periodicity: 1, 2, 4, and 6 months. Many institutions screen before discharge, but no formal universal AAP birth-hospitalization time point was identified. EPDS or PHQ-9 may be used.
AAP Periodicity Schedule; AAP 2025 MEB report; USPSTF 2016
Guideline difference
AAP 2022 recommends universal predischarge measurement under KAS 5. The reviewed USPSTF position is an I statement rather than a supporting universal recommendation. Preserve these positions separately.
Detailed reference · Immunization & medical prevention
Monovalent HepB within 24 hours for medically stable infants weighing ≥2,000 g.
Nirsevimab or clesrovimab; AAP states no product preference.
>1,500 g: vitamin K1 1 mg IM within 6 hours. ≤1,500 g: 0.3–0.5 mg/kg IM. Document refusal and bleeding-risk counseling. No safe U.S. oral alternative is identified in the AAP statement.
Erythromycin 0.5% ointment to both eyes within 24 hours; USPSTF Grade A and legally required in most U.S. states per the synthesis. It prevents gonococcal, not chlamydial, conjunctivitis. International recommendations differ.
Preference-sensitive, not universal. The AAP 2012 policy expired in 2017 and was not reaffirmed. Requires informed consent, sterile technique and adequate analgesia; contraindicated with hypospadias, ambiguous genitalia or medical instability.
Keep the cord clean and dry. Identify anomalies, birth injury, jaundice, feeding problems, respiratory difficulty, abnormal tone/reflexes, or other illness; close the loop on every screening result.
DTaP, Hib, PCV, IPV, and rotavirus begin at 2 months rather than at birth in the reviewed schedule.
Detailed reference · Anticipatory guidance & lifestyle
Medical and daily-life prevention meet in feeding assessment, safe sleep, early warning signs, and a confirmed follow-up plan.
Breast milk exclusively for about 6 months when breastfeeding; initiate within the first hour, use skin-to-skin and feed 8–12 times/24 h. Otherwise use iron-fortified formula with safe preparation. Observe breastfeeding before discharge and at 3–5 days.
Supine every sleep; firm, flat, noninclined crib/bassinet with fitted sheet only; room-share without bed-sharing ≥6 months, ideally 12; no soft objects, overheating, head covering or home monitors for SIDS prevention.
Begin supervised awake tummy time after discharge; increase toward 15–30 total min/day by 7 weeks (AAP Level A).
Promote skin-to-skin and bonding; assess caregiver stress, sleep deprivation, support and adjustment; normalize crying and discuss PURPLE Crying.
No tobacco/nicotine in home or car (Level A). Avoid alcohol, marijuana, opioids and illicit drugs during breastfeeding or infant care; counsel against impaired caregiving.
Rear-facing car seat; not a sleep space outside travel. Rectal temperature ≥100.4°F (38°C) under 2 months is an emergency. Also address poor feeding, lethargy, breathing difficulty, persistent vomiting and reduced output.
Before discharge
Confirm the 3–5-day appointment for feeding, weight, and bilirubin reassessment; review jaundice, output, safe sleep, car-seat use, cord/circumcision care, hand hygiene, sick contacts, and how results will be communicated.
Detailed reference · When routine care changes
Alter HepB timing; use weight-based vitamin K; increase surveillance for jaundice, feeding difficulty and apnea; use corrected developmental age.
Use the HepB/HBIG pathways above and post-vaccination serology when maternal HBsAg is positive.
Cord-blood DAT and heightened jaundice surveillance.
NAS surveillance, possible prolonged hospitalization, toxicology when indicated and social-work involvement.
Ensure bloodspot, hearing, CCHD, vitamin K, ocular prophylaxis and HepB completion. The evidence does not specify which items require repeat verification, so no repeat interval is operationalized here.
Immediate state-protocol follow-up and confirmatory testing; alter discharge and specialty planning when needed.
Maternal vaccine product/timing, birth season and rare high-risk circumstances determine infant antibody use.
Document vitamin K refusal counseling. Treat elective circumcision as individualized and respect contraindications.
Evidence conflicts retained
Ocular prophylaxis
AAP/USPSTF support routine U.S. use; Canadian guidance recommends against routine use in the described context; European positions vary.
Elective circumcision
Expired AAP statement supports availability, not universal use; European societies are described as disagreeing.
Developmental screening
AAP surveillance now and formal screening later vs USPSTF insufficient evidence for universal screening of asymptomatic children.
Postpartum-depression timing
AAP formal time points begin at 1 month; many hospitals screen before discharge.
Vitamin K route
AAP recommends IM only in the U.S.; international multidose oral regimens are described but not fully sourced.
Bilirubin
AAP recommends universal predischarge measurement; the reviewed USPSTF position is an I statement.
S1 · American Academy of Pediatrics
Preventive Pediatric Health Care / Periodicity Schedule
2017; rolling updates
S2 · AAP / Bright Futures
Guidelines for Health Supervision, 4th edition
2017
S3 · American Academy of Pediatrics
Management of Hyperbilirubinemia in Newborns ≥35 Weeks
2022
S4 · American Academy of Pediatrics
Updated CCHD Screening Algorithm
2025
S5 · American Academy of Pediatrics
Vitamin K and the Newborn Infant
2022
S6 · American Academy of Pediatrics
Sleep-Related Infant Deaths: Updated Recommendations
2022
S7 · American Academy of Pediatrics
Breastfeeding and the Use of Human Milk
2022
S8 · CDC / ACIP
Child and Adolescent Immunization Schedule
2025; addendum 2025-07-02
S9 · American Academy of Pediatrics
Prevention of RSV Disease in Infants and Children
2025
S10 · U.S. Food and Drug Administration
Clesrovimab approval
2025-06-27
S13 · U.S. Preventive Services Task Force
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum
Grade A
S15 · American College of Obstetricians and Gynecologists
Newborn Screening and the Role of the Obstetrician-Gynecologist
2019
S17 · U.S. Preventive Services Task Force
Newborn hearing screening recommendation
Grade B
Direct source URLs were unavailable in the reviewed evidence, so references are identified by organization, title, and date rather than linked. Current state newborn-screening panels must be verified locally.
References & review
This clinician reference was last reviewed August 10, 2026. It is educational and does not replace individualized clinical care.
Evidence reviewed includes guidance from the American Academy of Pediatrics and Bright Futures, CDC/ACIP, USPSTF, HHS/ACHDNC, JCIH, ACOG, and FDA. Where recommendations differ, those differences are identified explicitly.